| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6819460 | Psychoneuroendocrinology | 2015 | 7 Pages |
Abstract
Different studies have described evidence for an association between leptin serum levels and craving in alcohol dependent patients. As leptin expression is regulated by DNA methylation we investigated changes of DNA methylation of the LEP gene promoter region in alcohol dependent patients undergoing withdrawal. Results show that low methylation status is associated with increasing serum leptin levels and elevation of craving for alcohol in the referring patients group. These findings point towards a pathophysiological relevance of changes in DNA methylation of the LEP gene promoter region in alcohol dependence.
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Authors
Thomas Hillemacher, Christian Weinland, Bernd Lenz, Thomas Kraus, Annemarie Heberlein, Alexander Glahn, Marc A.N. Muschler, Stefan Bleich, Johannes Kornhuber, Helge Frieling,