Silica-supported heteropoly acids: Highly efficient catalysts for synthesis of α-aminonitriles, using trimethylsilyl cyanide or potassium cyanide

The multicomponent Strecker reaction using trimethylsilyle cyanide or potassium cyanide was performed in very short reaction times and α-aminonitriles were prepared in excellent yields in the presence of a catalytic amount of silica supported dodecatungstophosphoric acid. The simple experimental and product isolation procedure combined with easy recovery and reusability of the catalyst are expected to contribute to the development of clean and environmentally friendly strategy for the synthesis of α-aminonitriles.

Graphical abstractα-Aminonitriles were prepared in excellent yields and very short reaction times in the presence of silica supported H3PW12O40 (a heteropoly acid) as an environmentally friendly, inexpensive and reusable catalyst. Figure optionsDownload full-size imageDownload as PowerPoint slide