Iodine-catalyzed synthesis of novel Hantzsch N-hydroxyethyl 1,4-dihydropyridines under mild conditions

A mixture of ethanolamine and acetic acid as ethanolammonium acetate and various aldehydes in the presence of methyl acetoacetate were converted to N-hydroxyethyl 1,4-dihydropyridines under mild and solvent-free conditions in good to excellent yields. Reactions occurred both in the presence and in the absence of molecular iodine. Molecular iodine catalyzed the described reaction efficiently and also improved the reaction yields.

Graphical abstractA mixture of ethanolammonium acetate and various aldehydes in the presence of methyl acetoacetate were converted to N-hydroxyethyl 1,4-dihydopyridines under mild and solvent-free conditions in good to excellent yields. Molecular iodine catalyzed the described reaction efficiently and also improved the reaction yields.Figure optionsDownload full-size imageDownload as PowerPoint slide