| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6829874 | Seizure | 2018 | 16 Pages |
Abstract
In children with generalized seizures on VPA therapy, polymorphisms of UGT2B7, CYP3A4, and SCN1A genes were associated with seizure reduction. Larger studies are warranted to corroborate the results.
Keywords
ABATCYP2C9SCN1AVPAABCC2CYP3A4ABCB1SCNN-methyl-d-aspartateNMDAHWEMAFATP Binding Cassette Subfamily B Member 1UGT2B7FABP24-aminobutyrate aminotransferase95% CIgamma-aminobutyric acidGeneralized seizuresHardy-Weinberg equilibriumdrug-resistant epilepsy95% confidence intervalminor allele frequencyodds ratioSodium valproateGenetic polymorphismsSingle nucleotide polymorphismSNPChildrenGABAGRINGABA receptor
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Authors
Weixing Feng, Shenghui Mei, Leting Zhu, Yazhen Yu, Weili Yang, Baoqin Gao, Xiaojuan Wu, Zhigang Zhao, Fang Fang,