Organic base catalyzed O-alkylation of phenols under solvent-free condition

Several phenyl ethers were prepared under solvent-free condition at room temperature with good to excellent yields by simply grinding the mixture of relevant phenol, alkyl bromide, anhydrous potassium carbonate and organic base as catalyst in a mortar. This method is easy to handle and provides also a convenient procedure for protecting phenols in organic synthesis.

Graphical abstractSeveral phenyl ethers were prepared under solvent-free condition at room temperature with good to excellent yields by simply grinding the mixture of relevant phenol, alkyl bromide, anhydrous potassium carbonate and organic base as catalyst in a mortar. This method is easy to handle and provides also a convenient procedure for protecting phenols in organic synthesis. Figure optionsDownload full-size imageDownload as PowerPoint slide