| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 687218 | Chemical Engineering and Processing: Process Intensification | 2013 | 9 Pages |
A concept for the chiral resolution of racemic compounds by a combination of chiral pre-enrichment by continuous multi-column chromatography and final purification using selective crystallization is presented. The system of serine enantiomers in water represents a typical racemic compound-forming system with very high eutectic compositions in the chiral system, which is generally considered as unfavorable for selective crystallization. It is shown exemplarily, how the solvent and temperature-dependent formation of hydrates can be exploited to allow efficient chiral resolution by a combined process for this and similar systems.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Optimized coupling of SMB chromatography and selective crystallization. ► Alcohols suppress the formation of l-serine monohydrate. ► Eutectic composition depends of the solid state (hydrous/anhydrous) of l-serine. ► Purposeful shift of the eutectic composition exploited for chiral resolution.
