| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 68750 | Journal of Molecular Catalysis A: Chemical | 2006 | 10 Pages |
Abstract
Here we highlight our recent results of the application of ring-closing metathesis and ring-closing alkyne metathesis (RCAM) in biologically relevant biomolecules in order to introduce alkene- and/or alkyne-bridges as novel covalent constraints for stabilizing their bioactive conformation and increasing their metabolic stability.
Graphical abstractHere we highlight our recent results of the application of ring-closing metathesis and ring-closing alkyne metathesis in biologically relevant biomolecules in order to introduce alkene- and/or alkyne bridges as novel covalent constraints for stabilizing their bioactive conformation and increasing their metabolic stability.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Nourdin Ghalit, Dirk T.S. Rijkers, Rob M.J. Liskamp,