| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6877626 | Journal of Molecular Graphics and Modelling | 2015 | 9 Pages |
Abstract
- IB peptide binds to ICAM1 to block cytoadherence of RBCs towards ECs.
- The molecular modeling has identified the biophoric environment of IB peptide.
- IB peptide is optimized to block PfEMP1 binding region site on ICAM1.
- IBT 213 exhibits significant better interaction than template peptide.
- MD analysis indicates the stability of ICAM1:IBT213 model at ambient temperature.
- IBT213 does not block LFA-1 binding site on ICAM1.
- IBT213 has potential to develop blocking peptide to inhibit EC-RBC cytoadherence.
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
A. Mehra, Gaurav Jerath, Vibin Ramakrishnan, Vishal Trivedi,