| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6877632 | Journal of Molecular Graphics and Modelling | 2015 | 31 Pages |
Abstract
- Ligand based pharmacophore models were developed for PDE4B and PDE4D inhibitors.
- The developed pharmacophore model was validated by multiple approaches.
- Three different databases were screened by means of validated pharmacophore models.
- Docking analysis provided an insight into selective PDE4B inhibition.
- The results were confirmed by the in vitro evaluation of screened hits.
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Rahul P. Gangwal, Mangesh V. Damre, Nihar R. Das, Gaurao V. Dhoke, Anuseema Bhadauriya, Rohith A. Varikoti, Shyam S. Sharma, Abhay T. Sangamwar,