| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6877698 | Journal of Molecular Graphics and Modelling | 2014 | 7 Pages |
Abstract
- Substrates can be docked into the pocket of E386G mutant.
- The rescue mechanism is a concerted process with a calculated energy barrier of 22.6Â kcal/mol.
- The low barrier suggests that anionic formate might be a good nucleophile.
- The external nucleophile has little steric hindrance with pocket residues.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Jinhu Wang, Rui Zhang, Rutao Liu, Yongjun Liu,