| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6877749 | Journal of Molecular Graphics and Modelling | 2013 | 31 Pages |
Abstract
- The proton shuttle mechanism of saccharopine dehydrogenase was studied by DFT method.
- The residues Lys77 and His96 act as the acid-base catalysts in catalytic reaction.
- The hydride transfer step is rate limiting and the reaction is endothermic.
- The reverse reaction is more favored from energy point of view.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Xiang Sheng, Jun Gao, Yongjun Liu, Chengbu Liu,