| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6877755 | Journal of Molecular Graphics and Modelling | 2013 | 16 Pages |
Abstract
⺠We created homology-based models of full-length Hsp90s from N. crassa and S. cerevisiae. ⺠Experimental data guided our reconstruction of flexible regions in both proteins. ⺠A novel multi-domain interaction near the C-terminus of Hsp90 dimers was uncovered. ⺠The structural basis of differences in ATPase activity of fungal Hsp90s was studied. ⺠Binding to ATP, but not ADP, is affected by sequence of the 'lid' region in Hsp90s.
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Authors
Samir S. Roy, Robert W. Wheatley, Manju Kapoor,