Article ID Journal Published Year Pages File Type
6877770 Journal of Molecular Graphics and Modelling 2013 6 Pages PDF
Abstract

- We investigated the effect of TR heterodimerization on T3 dissociation.
- TR heterodimerization causes complete loss of pathway I in TR α-RXR LBD.
- The second dominant dissociation pathway switched after TR heterodimerization.
- Mechanisms of T3 egress were elucidated at atomic level.
Keywords
Related Topics
Physical Sciences and Engineering Chemistry Physical and Theoretical Chemistry
Preview
Molecular modeling revealed that ligand dissociation from thyroid hormone receptors is affected by receptor heterodimerization
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