Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6877776 | Journal of Molecular Graphics and Modelling | 2013 | 9 Pages |
Abstract
- Similarity screening yields new molecules with tubulin binding affinities.
- One of the new molecules possesses a novel highly rigid scaffold.
- Modifications of the new hits produce great binding enhancements.
- Rescoring the binding energies confirms findings.
- Physicochemical properties of novel ligands are superior to known tubulin binders.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Ahmed T. Ayoub, Mariusz Klobukowski, Jack Tuszynski,