Article ID Journal Published Year Pages File Type
6877776 Journal of Molecular Graphics and Modelling 2013 9 Pages PDF
Abstract

- Similarity screening yields new molecules with tubulin binding affinities.
- One of the new molecules possesses a novel highly rigid scaffold.
- Modifications of the new hits produce great binding enhancements.
- Rescoring the binding energies confirms findings.
- Physicochemical properties of novel ligands are superior to known tubulin binders.
Related Topics
Physical Sciences and Engineering Chemistry Physical and Theoretical Chemistry
Authors
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