| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6877778 | Journal of Molecular Graphics and Modelling | 2013 | 11 Pages |
Abstract
- The “in silico” 3D structure of folate receptor α is obtained by homology modeling.
- The expected network of 8 disulfide bridges of the receptor is successfully reproduced.
- The key structural determinants driving high affinity for folates analogs are suggested.
- The effect of some point mutation impairing folate binding is explained by this model.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Stefano Della-Longa, Alessandro Arcovito,