| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 690383 | Journal of the Taiwan Institute of Chemical Engineers | 2016 | 8 Pages |
•Production of MEF–PVP composites was performed by GAS.•An increase in drug-to-polymer ratio resulted in a higher % drug content.•An increase in temperature or drug-to-polymer ratio resulted in larger particle size.•MEF–PVP composites could dissolve 7 times faster than the unprocessed MEF.
In this study, composites of mefenamic acid (MEF) and polyvinylpyrrolidone K30 (PVP K30, MW ∼ 40,000) were synthesized by applying the Gas Anti-Solvent (GAS) technique. It was found that an increase in drug-to-polymer ratio resulted in a higher % drug content. However, temperature and solution concentration had no significant effect on the % drug content when the amount of polymer in the solution was lower than or equal to that of the drug. The dissolution rate of the MEF−PVP composites was found to be 7 times and 3 times greater than those of the unprocessed MEF and physical mixture, respectively.
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