| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 690443 | Journal of the Taiwan Institute of Chemical Engineers | 2016 | 7 Pages |
•Gelatin was incorporated by PLGA or PLGA-NH2 to produce drug-carrier hydrogel films to delivery hydrophobic drugs.•Gtn/PLGA and Gtn/PLGA-NH2 hydrogel films are homogeneous.•The compressional stress of Gtn/PLGA and Gtn/PLGA-NH2 films are marked high compared with that of Gtn film.•The Gtn/PLGA-NH2 hydrogel film has high load of IDM, low burst release, and sustained release of IDM up to 96 h.
Gelatin (Gtn) is a biodegradable and non-immunogenic biopolymer. However, Gtn materials have limited mechanical properties, especially in aqueous solutions. Additionally, since Gtn materials have high hydrophilicity, delivering a high load with a sustained releases of hydrophobic drugs is difficult. To overcome these drawbacks, Gtn-based hydrogel films are incorporated into a low concentration of PLGA and aminolyzed PLGA (e.g., PLGA-NH2) for the delivery of hydrophobic drugs; indomethacin (IDM), as a model, is crosslinked with different concentrations of 1,6-hexamethylene diisocyanate (HMDI) in a DMSO solution. Water contact angles were increased by incorporating PLGA (e.g., 53.9° ± 2.2° and 61.0° ± 0.9° for Gtn and Gtn/PLGA, respectively). The glass transition temperature values for Gtn, Gtn/PLGA and Gtn/PLGA-NH2 films were decreased by incorporating PLGA. The compressional stress of Gtn, Gtn/ PLGA and Gtn/ PLGA-NH2 hydrogel films was 8.9 ± 0.7, 15.5 ± 2.2 and 11.2 ± 0.8 kPa, respectively. The biocompatible Gtn/PLGA-NH2 hydrogel films had high IDM encapsulation efficiencies (e.g., roughly 84.8%) with low burst releases, sustained IDM release up to 96 h and the highest accumulative releases (e.g., 76.6 ± 3.7%) among the hydrogel films while concentrations of HMDI highly influenced the release characteristics of IDM in the films.
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