| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 69171 | Journal of Molecular Catalysis A: Chemical | 2006 | 4 Pages |
Nickel appears the most promising for the replacement of palladium among the inexpensive transition metals for that it is active for Heck reaction and about 500 times cheaper than palladium. In this article, we describe our recent results in the area of nickel-catalyzed Heck vinylations. Main focus is on the influence of ligand concentration in different organic solvents and the effects of the addition of water. The conversion is high in NMP and increases with increasing of PPh3/Ni ratio; in ethanol and toluene the conversion presents a maximum value on Ni(PPh3)2. The effect of the addition of water is sensitive to the concentration of PPh3 and the nature of solvent, it was well explained with the formation and transfer of the active species in the different solvent systems.
Graphical abstractNickel appears the most promising for the replacement of palladium among the inexpensive transition metals, the effect of the addition of water is sensitive to the concentration of PPh3 and the nature of solvent in nickel-catalyzed Heck reactions.Figure optionsDownload full-size imageDownload as PowerPoint slide
