Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
69291 | Journal of Molecular Catalysis A: Chemical | 2006 | 8 Pages |
A comparative study of the ligand (5–10) effect on the rhodium catalytic activity and selectivity in the homogeneous hydrogenation of α,β-unsaturated oxosteroids (1–4) is reported. The highest activity for CC reduction was observed with phosphite ligands, being diphosphite 10 the most active. Furthermore, the presence of phosphite 6 significantly enhances the chemo and α-diastereoselectivity for the hydrogenation reaction. The β-methyl groups of the steroidal framework lead to a very high α-diastereoselectivity, even in the absence of phosphorous ligands. Substrate 4 is the paradigm presenting higher than 94% α-diastereoselectivity for any catalytic system studied.The catalytic system formed from rhodium and the new diphosphite 10 also revealed a remarkable tendency for the CO reduction and a noteworthy stability.
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