Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6956744 | Photoacoustics | 2018 | 8 Pages |
Abstract
Dynamic contrast-enhanced Multispectral Optoacoustic Tomographic imaging (DCE-MSOT) acquires serial MSOT images with the administration of an exogenous contrast agent over time. We tracked the dynamics of a tumor-targeted contrast agent, HypoxiSense 680 (HS680), in breast xenograft mouse models using MSOT. Arterial input function (AIF) approach with MSOT imaging allowed for tracking HS680 dynamics within the mouse. The optoacoustic signal for HS680 was quantified using the ROI function in the ViewMSOT software. A two-compartment pharmacokinetics (PK) model constructed in MATLAB to fit rate parameters. The contrast influx (kin) and outflux (kout) rate constants predicted are kinâ=â1.96âÃâ10â2âs-1 and koutâ=â9.5âÃâ10-3âs-1 (Râ=â0.9945).
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Authors
Ted G. Xiao, Jared A. Weis, F. Scott Gayzik, Alexandra Thomas, Akiko Chiba, Metin N. Gurcan, Umit Topaloglu, Abhilash Samykutty, Lacey R. McNally,