Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6956853 | Photoacoustics | 2018 | 34 Pages |
Abstract
In this paper we establish a methodology to predict photoacoustic imaging capabilities from the structure of absorber molecules (sonochromes). The comparative in vitro and in vivo screening of naphthalocyanines and cyanine dyes has shown a substitution pattern dependent shift in photoacoustic excitation wavelength, with distal substitution producing the preferred maximum around 800Â nm. Central ion change showed variable production of photoacoustic signals, as well as singlet oxygen photoproduction and fluorescence with the optimum for photoacoustic imaging being nickel(II). Our approach paves the way for the design, evaluation and realization of optimized sonochromes as photoacoustic contrast agents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Spectroscopy
Authors
Mitchell J. Duffy, Oriol Planas, Andreas Faust, Thomas Vogl, Sven Hermann, Michael Schäfers, Santi Nonell, Cristian A. Strassert,