Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
696282 | Automatica | 2011 | 5 Pages |
Abstract
The concept of elementary flux vector is valuable in a number of applications of metabolic engineering. For instance, in metabolic flux analysis, each admissible flux vector can be expressed as a non-negative linear combination of a small number of elementary flux vectors. However a critical issue concerns the total number of elementary flux vectors which may be huge because it combinatorially increases with the size of the metabolic network. In this paper we present a fast algorithm that randomly computes a decomposition of admissible flux vectors in a minimal number of elementary flux vectors without explicitly enumerating all of them.
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Authors
Raphael M. Jungers, Francisca Zamorano, Vincent D. Blondel, Alain Vande Wouwer, Georges Bastin,