Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6972706 | Journal of Hazardous Materials | 2011 | 14 Pages |
Abstract
The aim of this study is to investigate the chronic effect of some cement components on the content of ions in different brain areas in adult male albino mice. It is clear that chronic intraperitoneal administration of 0.0013Â mg/g aluminum ion caused a significant increase in aluminum, calcium and sodium ions and significant decrease in iron ions, the chronic intraperitoneal administration of 0.00065Â mg/g iron caused a significant increase in iron, calcium, and sodium ions but No significant change in potassium and aluminum ions. Chronic intraperitoneal administration of 0.0013Â mg/g silicon caused no significant change in calcium, potassium, sodium, aluminum and iron. Chronic intraperitoneal administration of 0.0013Â mg/g aluminum, 0.0013Â mg/g silicon and 0.00065Â mg/g iron, respectively, - using separating time interval 30Â min between each - caused a higher elevation in calcium, sodium, aluminum and iron concentrations than the elevation in other groups and no significant change in potassium ions. This may be due to the elevation in glutamate which leads to increase in the intracellular of calcium concentration and the inhibition of membrane-bound Na+, K+, Ca2+ ATPase activity which lead to cellular alterations and may be death. So long-term exposure to cement components as environmental pollutants may lead to neurodegenerative diseases.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Health and Safety
Authors
M. Abd El-Rahman, M.F. El-Khadragy, H. Abd-El Hay, D.M. Gab-Allah,