| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6981180 | Colloids and Surfaces B: Biointerfaces | 2015 | 35 Pages |
Abstract
- PAMAM-DOX conjugates (FPP-hyd-DOX) with different FA ratios were constructed and identified.
- In vitro evaluations exhibited the conjugates release DOX in an obvious pH-triggered manner.
- FPP-hyd-DOX was internalized by KB cells via clathrin-mediated endocytosis.
- Subcellular localization study revealed drug release of FPP-hyd-DOX was triggered in lysosomes.
- FPP-hyd-DOX conjugations would be a promising drug delivery carrier for targeted cancer therapy.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Lifang Cheng, Qing Hu, Liang Cheng, Wen Hu, Ming Xu, Yaqin Zhu, Lu Zhang, Dawei Chen,