Targeting delivery of tocopherol and doxorubicin grafted-chitosan polymeric micelles for cancer therapy: In vitro and in vivo evaluation

- We synthesized targeting ligand-modified multidrug grafted polymeric micelle (HPTOC-DOX).
- HPTOC-DOX formed micelles of approximately 151.9-311.2 nm in size in aqueous solution.
- Doxorubicin was released from HPTOC-DOX micelles at acidic pH 5.2 or 6.2.
- In vitro and in vivo anti-tumor assays showed higher anti-cancer activity than target peptide un-modified polymeric micelles.