Tailoring of the titanium surface by preparing cardiovascular endothelial extracellular matrix layer on the hyaluronic acid micro-pattern for improving biocompatibility

- A bionic coating composed of endothelial ECM and HA micro-pattern was prepared on the Ti surface.
- This bionic surface was demonstrated to possess better hemocompatibility and EPCs compatibility.
- This bionic surface could inhibit the proliferation of SMCs and the attachment of macrophages.
- This bionic surface is expected to be potentially applied for the blood contact devices.