| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6981970 | Colloids and Surfaces B: Biointerfaces | 2015 | 9 Pages |
Abstract
- We prepared siRNA-PLGA conjugates via a disulfide linkage and siRNA-PLGA/CSO micelles were produced via ionic complexation.
- The stable, spherical siRNA-PLGA/CSO micelles with size of 150-180Â nm showed more stable in RNase solution.
- The siRNA-PLGA/CSO micelles exhibited superior cellular uptake and STAT3 gene silencing efficiency in SKOV3 cells.
- The siRNA-PLGA/CSO micelles showed to inhibit the growth of SKOV3 cells and promote the apoptosis of cells.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Yunchun Zhao, Caihong Zheng, Li Zhang, Yue Chen, Yiqing Ye, Mengdan Zhao,