Surface engineered and ligand anchored nanobioconjugate: An effective therapeutic approach for oral insulin delivery in experimental diabetic rats

- The ligand anchored PEGylated insulin loaded PPC nanoparticles resulted in extended residence time of glucose.
- PPC nanoparticulate system can be a promising drug delivery carrier for oral insulin delivery in the treatment of diabetes mellitus.
- The insulin delivery through PPC nanoparticulate system helps extending insulin stay in the blood circulation with enhanced oral bioavailability through targeted approach.
- The reduction of blood glucose level to safer limits for extended period proves efficacy of PEGylated PLGA nanoparticulate system.
- The potential of this ligand anchored nanoparticle for the oral drug delivery should be investigated further to address the one of the most prevalent disorders in India.