Bacterial protease triggered release of biocides from microspheres with an oily core

- Describes an “intelligent” microcapsule material that degrades and releases an active substance upon stimuli from virulent bacteria (Staphylococcus aureus).
- Choice of nanofilm components (microcapsule shell), particularly the terminating film, after study of bacterial exoproduct with very high substrate specificity.
- Crosslinking of the microcapsule shell (nanofilm) to resist human wound enzymes (human neutrophil elastase).
- Oily core allowing storage of hydrophobic antimicrobial substances or substances subjected to hydrolysis in a hydrophilic environment, in this case dermis.