Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6982147 | Colloids and Surfaces B: Biointerfaces | 2015 | 8 Pages |
Abstract
- Three nanoassemblies based on a cheap cationic lipid, didodecyldimethylammonium bromide (DDAB) as gene vectors.
- The key components including oleic acid (OA), cholesterol (Chol), cholesteryl succinyl poly(ethylene glycol) 1500 (CHS-PEG), poly(d,l-lactide-co-glycolide)-methoxy-poly(ethylene glycol) (PLGA-PEG).
- The optimal component ratios in the nanoassemblies according to Langmuir monolayer behavior.
- Firstly compressing DNA or siRNA with the cationic lipid (i.e., DDAB) and secondly coated with the helper lipids (OA and CHS-PEG) of CPNA or the helper polymer (PLGA-PEG) of PPNA.
- CPNA and PPNA had the advantages of no cytotoxicity, high transfection efficiency, low cost and no sensitivity to serum.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Yiguang Jin, Shuangmiao Wang, Li Tong, Lina Du,