Article ID Journal Published Year Pages File Type
6982147 Colloids and Surfaces B: Biointerfaces 2015 8 Pages PDF
Abstract

- Three nanoassemblies based on a cheap cationic lipid, didodecyldimethylammonium bromide (DDAB) as gene vectors.
- The key components including oleic acid (OA), cholesterol (Chol), cholesteryl succinyl poly(ethylene glycol) 1500 (CHS-PEG), poly(d,l-lactide-co-glycolide)-methoxy-poly(ethylene glycol) (PLGA-PEG).
- The optimal component ratios in the nanoassemblies according to Langmuir monolayer behavior.
- Firstly compressing DNA or siRNA with the cationic lipid (i.e., DDAB) and secondly coated with the helper lipids (OA and CHS-PEG) of CPNA or the helper polymer (PLGA-PEG) of PPNA.
- CPNA and PPNA had the advantages of no cytotoxicity, high transfection efficiency, low cost and no sensitivity to serum.
Related Topics
Physical Sciences and Engineering Chemical Engineering Colloid and Surface Chemistry
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