| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6982277 | Colloids and Surfaces B: Biointerfaces | 2015 | 10 Pages |
Abstract
- CGA-ODNs were introduced to load Dox without any modification of carriers or drugs and five Dox could be loaded in one CGA-ODN.
- Based on electrostatic interaction, Dox and siRNA could be co-loaded. Cellular internalization of PDR demonstrated the co-loading and co-delivery effect with mono-loading process.
- CLSM images confirmed the targeted cellular uptake and successful lysosomal escape of siRNA and Dox. Nuclear localization of Dox was also observed clearly.
- In vitro drug release and cellular uptake confirmed the pH sensitivity of CPN, another mechanism of internalization.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Tingxian Liu, Mingfang Wang, Tianqi Wang, Yao Yao, Na Zhang,