Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6982285 | Colloids and Surfaces B: Biointerfaces | 2015 | 37 Pages |
Abstract
The aim of this study was to develop self emulsifying drug delivery systems (SEDDS) of glipizide and to convert it into solid SEDDS (S-SEDDS) using Syloid® 244 FP as adsorbent. Solubility study, ternary phase diagram, robustness to dilution, thermodynamic stability study and globule size analysis were adopted to optimize liquid SEDDS. S-SEDDS were evaluated for various studies including in vivo study. The optimized liquid SEDDS formulation consisted of phosphatidylcholine, Tween 80 and Transcutol P as oil, surfactant and cosolvent. In vivo study demonstrated that blood glucose levels were efficiently controlled with S-SEDDS compared with pure drug. The results of this study suggest the potential use of developed S-SEDDS formulation for the delivery of poorly water-soluble drug glipizide.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Anuj G. Agrawal, Ashok Kumar, Paraag S. Gide,