| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6982342 | Colloids and Surfaces B: Biointerfaces | 2014 | 11 Pages |
Abstract
- Methotrexate and zoledronic acid loaded into tecto-dendrimers (MTX- and ZOL-sandwiches) are proposed to enhanced activity of the drugs on melanoma cells.
- MTX- and ZOL-sandwiches showed higher cytotoxicity to melanoma cells than free drugs and tecto-dendrimers alone.
- MTX-sandwiches was cytotoxic to melanoma cells and harmless to keratinocytes.
- MTX-sandwiches was uptaken by macropinocytosis avoiding methotrexate exocytosis.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Priscila Schilrreff, Gabriela Cervini, Eder Lilia Romero, Maria Jose Morilla,