| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6982452 | Colloids and Surfaces B: Biointerfaces | 2014 | 28 Pages |
Abstract
- A systematic comparison of the effect of Ch-SeNPs vs. other selenocompounds on hepatocarcinoma cells in terms of proliferation, apoptosis and cell cycle pattern has been carried out.
- Cells exposed to Se(VI), seleno methylselenocysteine and selenomethionine do not exhibit a different behavior as compared to control cells at the tested concentrations.
- Se(IV) induce a significant degree of apoptosis proving to be the most toxic selenospecies assayed.
- Ch-SeNPs and selenocystine exposure induced a cell cycle arrest at the S-G2/M phase.
- Ch-SeNPs showed a unique potential for targeting mitosis by partially inhibiting the expression of cyclin-dependent kinase 1 (Cdk1).
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Hector Estevez, J. Carlos Garcia-Lidon, Jose L. Luque-Garcia, Carmen Camara,