| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6982501 | Colloids and Surfaces B: Biointerfaces | 2014 | 10 Pages |
Abstract
- Folate-PEL-β-CD, an amphiphilic copolymer using β-cyclodextrin as the natural star core and folate-conjugated poly(ethylene glycol)-poly(lactide) segments as the shell, was synthesized.
- The treatment with 10Â mg/kg DOX loaded FA-PEL-CD micelles achieved approximately 86% of tumor growth inhibition compared to the control.
- Ex vivo fluorescence imaging experiments and histological examination confirmed that folate modification can enhance the antitumorigenesis efficacy and reduce the cardiotoxicity of DOX.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Lu Zhang, Jiafei Lu, Yangmin Jin, Liyan Qiu,