Targeted delivery of doxorubicin into tumor cells via MMP-sensitive PEG hydrogel-coated magnetic iron oxide nanoparticles (MIONPs)

- MMP-sensitive and RGDS functional PEG hydrogel coating around MIONPs is developed.
- Multifunctional coating induces targeted drug release into cancer cells.
- Cancer cell viability was compromised within 2 h via targeted drug release.
- Drug loaded nanoparticles have minimum cytotoxic damage to healthy cells.
- The approach will be useful for cancer cell diagnosis and targeted drug delivery.