Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6983098 | Colloids and Surfaces B: Biointerfaces | 2014 | 9 Pages |
Abstract
- A series of cholesterol-based lipid gene carriers were prepared from natural product derived building blocks.
- The cationic headgroups play more important roles than linkages in the physico-chemical properties of the cholesterol-based cationic lipids.
- The cytotoxicity and gene transfection in COS-7 and HeLa cells depend greatly on the types of headgroups.
- The l-lysine headgroup bearing lipids demonstrate very high gene transfection efficacy.
- The correlation between intracellular uptake and gene transfection capacity was studied.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Ruilong Sheng, Ting Luo, Hui Li, Jingjing Sun, Zhao Wang, Amin Cao,