| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6983490 | Colloids and Surfaces B: Biointerfaces | 2014 | 9 Pages |
Abstract
- Quaternised poly(propylene imine) dendrimer of generation-3, QPPI (G3), is expected to serve as drug carrier for poorly soluble drugs like nimesulide, NMD.
- QPPI (G3) forms complex with NMD which reflects in significant drug loading potential.
- This complexation leads to increase the solubility and sustains the release of NMD under in vitro conditions.
- QPPI (G3) has reduced the cytotoxicity in comparison with PPI (G3) dendrimer.
- QPPI (G3) is a promising candidate in the design of polymeric drug delivery systems to enhance the bioavailability of the poorly soluble drugs.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
E. Murugan, D.P. Geetha Rani, V. Yogaraj,