Human vascular endothelial cell morphology and functional cytokine secretion influenced by different size of HA micro-pattern on titanium substrate

- The HMW-HA stripes can effectively regulate the shape and cytokine secretion of ECs.
- The cytokine secretion of ECs was closely linked to the cell shape, especially the L/B index.
- The anticoagulation property of the ECs was also modulated by their sizes and the micro-pattern.
- The micro-pattern may be potential useful for blood contact devices.