| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6984002 | Colloids and Surfaces B: Biointerfaces | 2013 | 9 Pages |
Abstract
- PVA microbubbles are coated with chitosan-galactosylated (GC) to target hepatocarcinoma.
- GC confer specificity for asialoglycoprotein receptor (ASGPR).
- GC-microbubbles show bioadhesive properties/selectivity for tumor cells expressing ASGPR.
- Doxorubicin-loaded particles display higher cytotoxic activity than the free drug.
- Cytotoxicity of GC-microbubbles /doxorubicin is increased upon exposure to ultrasound.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Raffaella Villa, Barbara Cerroni, Lucia Viganò, Silvia Margheritelli, Gabriella Abolafio, Letizia Oddo, Gaio Paradossi, Nadia Zaffaroni,