Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6984076 | Colloids and Surfaces B: Biointerfaces | 2012 | 11 Pages |
Abstract
⺠Non-solvent crystallisation is potential to prepare lactose particles with favourable properties. ⺠The poorer the flowability of lactose powders the lower drug emission from inhaler device. ⺠Reduction in drug-carrier adhesion properties was obtained with engineered lactose particles. ⺠Lactose powders with higher bulk density showed higher amounts of drug deposited in the lung. ⺠Drug content uniformity for DPI formulation is depended on carrier flowability and particle size.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Waseem Kaialy, Gary P. Martin, Hassan Larhrib, Martyn D. Ticehurst, Ewa Kolosionek, Ali Nokhodchi,