| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6984269 | Colloids and Surfaces B: Biointerfaces | 2012 | 7 Pages |
Abstract
⺠We study the tendency of insulin to form amyloid spherulites and fibrils. ⺠We report a statistical method to estimate the balance of spherulites and fibrils. ⺠Spherulites are the dominant aggregation pathway at low pH and protein concentration. ⺠Protein concentration affects the balance between free fibrils and spherulites. ⺠pH changes around 2 largely affect the final spherulite size.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Michael I. Smith, Vito Foderà , James S. Sharp, Clive J. Roberts, Athene M. Donald,