Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7044232 | Separation and Purification Technology | 2017 | 27 Pages |
Abstract
In this study, a thermo-sensitive polymer Poly(MAH-β-CD-co-NIPAAm) was synthesized by the copolymerization of N-isopropylazylamide (NIPAAm) with the maleic anhydride (MAH) modified β-cyclodextrin (β-CD). This polymer was both used as chiral selector and phase-forming component of aqueous two-phase system (ATPS). ATPS formed by Poly(MAH-β-CD-co-NIPAAm) and dextran T40 was used for chiral separation of mandelic acid (MA) enantiomers. The influencing parameters of the distribution behavior of MA were studied, viz. concentration of thermo-sensitive polymer, pH, operational temperature, and initial MA concentration. The results showed that this chiral selector preferentially recognizes the (S)-enantiomer rather than the (R)-enantiomer, the maximum separation factor (α) can reach to 1.27 under the optimum conditions. The thermo-sensitive polymer can be recycled by heating and centrifugation after enantioseparation. This ATPS is a simple, green and economical approach for the chiral separation of MA and other chiral enantiomers.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Filtration and Separation
Authors
Zhijian Tan, Fenfang Li, Congcong Zhao, Yubin Teng, Yanfei Liu,