Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7061976 | Thermochimica Acta | 2018 | 20 Pages |
Abstract
The study evaluates the use of differential scanning calorimetry (DSC) in differentiating the severity of Parkinson's disease (PD). The heat capacity profiles and thermodynamic parameters of serum denaturation transition in advanced PD deviate significantly from the age-matched healthy controls. Unfortunately, blood serum calorimetry does not indicate the early stages of the disease. The amplitude of the main transition and the enthalpy of serum denaturation are significantly reduced with advanced disease. Statistically significant, inverse correlations have been found between these parameters and age as well as disease severity. Significantly higher mean temperature of the second transition at about 70â¯C, has been observed for PD patients in comparison with healthy participants but only small its deviations have appeared across disease groups. Results of the study indicate that DSC can be used as complementary bioanalytical tool for the monitoring of disease-related changes in serum and PD progression.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Fluid Flow and Transfer Processes
Authors
Anna Michnik, Ewa Sadowska-KrÄpa, Joanna Cholewa, Izabela Schisler, Agnieszka KieÅboÅ, Zofia Drzazga,