| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7069512 | Bioresource Technology | 2017 | 39 Pages |
Abstract
Succinic acid is a four-carbon dicarboxylic acid, which has attracted much interest due to its abroad usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Facing the shortage of crude oil supply and demand of sustainable development, biological production of succinic acid from renewable resources has become a topic of worldwide interest. In recent decades, robust producing strain selection, metabolic engineering of model strains, and process optimization for succinic acid production have been developed. This review provides an overview of succinic acid producers and cultivation technology, highlight some of the successful metabolic engineering approaches.
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Authors
Min Jiang, Jiangfeng Ma, Mingke Wu, Rongming Liu, Liya Liang, Fengxue Xin, Wenming Zhang, Honghua Jia, Weiliang Dong,