Modeling and control of pharmacodynamics

Modeling and control of drug dosing regimes are particularly well-suited for applications of control design and analysis techniques. These problems frequently incorporate the use of mathematical models, lending themselves to a large range of model-based control methods. There has been ongoing research aimed at the development of closed-loop drug dosing and delivery regimens in a number of specific medical domains for more than five decades. In this paper, we discuss the development of modeling and control methods aimed at closed-loop delivery of pharmaceutical agents. We focus most of this discussion on the problem of controlling sedation levels during surgical procedures; results from the application of linear parameter varying and robust L1-adaptiveL1-adaptive modeling and control approaches are presented in some detail.