Article ID Journal Published Year Pages File Type
7087729 Bioresource Technology 2012 8 Pages PDF
Abstract
► o-Chloroacetophenone and its reduction product are highly toxic to enzymes and cells. ► Properties of substrate and product guided comprehensive bioprocess engineering. ► Substrate supply and product removal were optimized. ► Mass transfer limitations were overcome by cell permeabilization. ► (S)-1-(2-chlorophenyl)ethanol was obtained in high optical purity and yield.
Related Topics
Physical Sciences and Engineering Chemical Engineering Process Chemistry and Technology
Authors
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