Article ID Journal Published Year Pages File Type
713982 IFAC Proceedings Volumes 2013 6 Pages PDF
Abstract

The cultivation of animal cells in perfusion allows the production of various biopharmaceutical products. In this work, the observability properties of a nonlinear dynamic model of these animal cell cultures is assessed using a method based on a natural dynamical interpretation of the observability/detectability concepts, leading to the description of the indistinguishable dynamics of the system. Following this analysis, a Kalman filter is designed to reconstruct on-line variables which are difficult or expensive to measure directly with a hardware sensor.

Related Topics
Physical Sciences and Engineering Engineering Computational Mechanics