Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
713982 | IFAC Proceedings Volumes | 2013 | 6 Pages |
Abstract
The cultivation of animal cells in perfusion allows the production of various biopharmaceutical products. In this work, the observability properties of a nonlinear dynamic model of these animal cell cultures is assessed using a method based on a natural dynamical interpretation of the observability/detectability concepts, leading to the description of the indistinguishable dynamics of the system. Following this analysis, a Kalman filter is designed to reconstruct on-line variables which are difficult or expensive to measure directly with a hardware sensor.
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