Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7155592 | Communications in Nonlinear Science and Numerical Simulation | 2015 | 17 Pages |
Abstract
Thyroid's main chemical reactions are employed to develop a mathematical model. The presented model is based on differential equations where their dynamics reflects many aspects of thyroid's behavior. Our main focus here is the well known, but not well understood, phenomenon so called as Wolff-Chaikoff effect. It is shown that the inhibitory effect of intake iodide on the rate of one single enzyme causes a similar effect as Wolff-Chaikoff. Besides this issue, the presented model is capable of revealing other complex phenomena of thyroid hormones homeostasis.
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Authors
Gholam Reza Rokni Lamooki, Amir H. Shirazi, Ali R. Mani,