| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 716736 | IFAC Proceedings Volumes | 2012 | 6 Pages |
Previous research on crystallization processes has demonstrated that through tracking an optimum temperature or supersaturation profile obtained through optimisation using a multi-dimensional or morphological population balance (M-PB) model, the shape of rod-likeL-Glutamic acid crystals, as defined as the ratio between the mean length and the mean width, can be optimized and close-loop controlled. The current paper is concerned with optimization and control of shape distribution for a population of crystals grown from solution. An optimisation algorithm was applied to an M-PB model developed for L-glutamic acid crystallisation to find the optimal profile of supersaturation that leads to the desired shape distributionof β-form rod-like product crystals. A closed-loop feedback control system was designed to control the solution concentration to track the optimum trajectory. On a one litre crystalliser, it was demonstrated that crystals of different shape distributions can be obtained using the developed closed-loop control methodology.
